coronary heart disease
Conditions
Interventions
group s:Dilute 0.6mL/kg of Shenmai Injection to 250mL using 5% glucose injection, and administer intravenously at a rate of 150ml/h at the beginning of the surgery.
group c:Start intravenous infusion of 150 mL of 5% glucose injection at a rate of 150 ml/h during surgical skin cutting
Sponsors
Dongyang People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: a. Age range from 45 to 75 years old; b. ASA classification II-IV, grade; c. Body mass index 18.5-30kg/m ².
Exclusion criteria
Exclusion criteria: a. Patients with allergies to Shenmai injection; b. Patients who need to undergo coronary artery bypass surgery under extracorporeal circulation during surgery; c. Pregnant and lactating women; d. Severe left ventricular dysfunction (EF<35%), e. Preoperative respiratory failure (PaO2<60mmHg), f. Severe uncontrolled hypertension or hypotension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatine kinase isoenzyme; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;heart rate;Troponin;BNP;Heart index;Left ventricular ejection fraction;Blood lactate;Interleukin-6;Superoxide dismutase;Extubation time;ICU stay time;Length of hospital stay;Cardiovascular adverse events at 30 days postoperatively;Procalcitonin; | — |
Countries
China
Contacts
Public ContactLiu Ying
Dongyang People's Hospital
Outcome results
None listed