The effect of chrono-electroacupuncture on ischemic stroke and its mechanism based on the circadian clock gene rev-erb?

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400086901

Enrollment

Unknown

Registered

2024-07-15

Start date

2024-07-16

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke

Interventions

EA group in the morning:Foundation treatment and EA from 9 to 11 a.m

EA group in the afternoon:Foundation treatment and EA from 3 to 5 p.m

Control group:Foundation treatment

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) IS the diagnosis standard; (2) the onset of 1 to 10 days; (3) limb hemiplegia, walking/eating/dress cannot independently; (4) 18 years old = age =80 years old, regardless of gender; (5) understand and agree to participate in this study, voluntarily signed informed consent.

Exclusion criteria

Exclusion criteria: (1) daily life ability barrier exists before the onset of cerebral apoplexy, walking/eating/dress cannot independently; (2) a serious speech, attention, hearing, vision, intelligence, mental or cognitive impairment, unable to cooperate with treatment and assessment (Montreal cognitive assessment scale (10 points); (3) there are serious complications or contraindications, complications, such as severe heart failure, acute myocardial infarction or unstable angina, aortic dissection, and renal failure, etc.; (4) fear of acupuncture, resist, or always appear serious treatment phenomenon such as inappropriate for acupuncture treatment and acupuncture area of selected point exist skin damage, infection, or ulcer.

Design outcomes

Primary

Measure	Time frame
National Institutes of Health Stroke Scale;	—

Secondary

Measure	Time frame
Montreal Cognitive Assessment;Pittsburgh Sleep Quality Index;Barthel index;Modified Rankin Scale;Platelet Count (PLT);Fibrinogen (FIB);D-dimer (DDi);White Blood Cell Count (WBC);C-Reactive Protein (CRP); Erythrocyte Sedimentation Rate (ESR);Plasma Homocysteine (Hcy);	—

Countries

China

Contacts

Public ContactDong Guirong

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine

dongguirong2000@126.com+86 189 3013 2113

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026