Type 2 Diabetes
Conditions
Interventions
Patient group:none
Healthy control group:none
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patient group: (1) Meet the 1999 WHO diabetes diagnostic criteria, diabetes course >1 year; (2) Age 18-80: (3) With or without cognitive impairment (MoCA or MMSE scale score is normal or below normal); (4) Right-handed; (5) The patient and his family members informed consent, compliance is good, voluntarily participate in clinical trial research. 2. Healthy control group: (1) Age 18-80 years (roughly matched with T2DM group): (2) Not accompanied by cognitive dysfunction (MoCA or MMSE scale score normal): (3) Right-handed; (4) Informed consent of the patient himself and his family members, good compliance, and voluntary participation in clinical trial research.
Exclusion criteria
Exclusion criteria: Patient group: (1) There are serious complications related to diabetes: such as diabetic nephropathy CKD5, diabetic diabetic disease retinopathy proliferative stage, severe diabetic neuropathy, diabetic foot, etc.; (2) brain structural abnormalities and other organic lesions in the brain, including the presence of tumors or a history of trauma, surgery or cerebrovascular accident; (3) History of stroke, epilepsy, traumatic brain injury and carbon monoxide poisoning; (4) A history of chronic neurological or psychiatric disorders, such as depression, dementia, or schizophrenia. (5) heart, liver, pancreas, spleen, kidney and other serious organ diseases; (6) History of metabolic diseases such as hyperthyroidism and hypothyroidism; (7) A long history of alcohol and drug abuse; (8) MRI scan contraindications such as pregnancy, dentures, claustrophobia; (9) Have taken drugs that affect brain function or blood flow within 3 weeks; Healthy control group: (1) There are serious complications related to diabetes: such as diabetic nephropathy CKD5, diabetic diabetic disease retinopathy proliferative stage, severe diabetic neuropathy, diabetic foot, etc.; (2) brain structural abnormalities and other organic lesions in the brain, including the presence of tumors or a history of trauma, surgery or cerebrovascular accident; (3) History of stroke, epilepsy, traumatic brain injury and carbon monoxide poisoning; (4) A history of chronic neurological or psychiatric disorders, such as depression, dementia, or schizophrenia. (5) heart, liver, pancreas, spleen, kidney and other serious organ diseases; (6) History of metabolic diseases such as hyperthyroidism and hypothyroidism; (7) A long history of alcohol and drug abuse; (8) MRI scan contraindications such as pregnancy, dentures, claustrophobia; (9) Have taken drugs that affect brain function or blood flow within 3 weeks;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PositronEmissionTomography/MagneticResonanceImaging brain scan; | — |
Countries
China
Contacts
Public ContactQingzhu Wang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed