Coronary heart disease
Conditions
Interventions
HFNO group:high-flow nasal cannula
SOT group:continuous flow oxygen delivery through nasal cannula
Sponsors
Department of Anesthesiology, Beijing Anzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Patients older than 18 years old. • Coronary heart disease patients scheduled for or requiring urgent GIE (upper and/or lower endoscopy), with plans for sedation aimed at maintaining spontaneous respiration (as determined during anesthesia consultation). • Coronary heart disease patients are defined as those with single or multiple coronary artery stenosis >50% as determined by coronary angiography.
Exclusion criteria
Exclusion criteria: • Necessity to intubate the patient for the procedure. • Patient under oxygen therapy at home. • Tracheostomised patient. • High risk of aspiration, inability to fully clear upper respiratory secretions, thick or excessive airway secretions, and ineffective cough for sputum clearance. • Hemodynamically unstable (sustained systolic arterial pressure <80 mmHg). • Severe heart failure (ejection fraction <45%). • Patients with severe cardiac arrhythmias (atrial fibrillation, frequent premature ventricular contractions, ventricular tachycardia, and second-degree or higher atrioventricular block). • Unresolved tension pneumothorax or mediastinal emphysema. • Combined with dysfunction of other organ systems (shock, gastrointestinal perforation/major bleeding, severe cerebral disorders, and severe hepatic or renal dysfunction).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiac circulatory efficiency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypotension, which hypotension defined by a systolic blood pressure less than 80 mmHg or 20% lower than the baseline value;BNP and TnI;Lactate levels;Occurrence of hypoxemia (defined as SpO2 =92%);Need for mask ventilation or any airway intervention;Frequency of patient agitation episodes (defined as touching the oxygen supply device);Intraoperative adverse memory recall;Duration of sedation (from induction to patient awakening);Mostcare monitoring data(excluding CCE);HFNO-related adverse events (such as xeromycteria/rhinalgia); | — |
Countries
China
Contacts
Public ContactSheng Wang
Beijing Anzhen Hospital
Outcome results
None listed