autism spectrum disorder
Conditions
Interventions
Control group:None
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
2 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1. ASD group: (1) Initial diagnosis (2) Diagnosis age 2-8 years old (3) Patients meeting the DSM-V diagnostic criteria for autism spectrum disorder and scores of CARS= 30; (4) Evidence of a subject (or a legal representative) signed and dated informed consent document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study and are willing to participate in it. 2. Control group: (1) Age 2-8 years old; (2) After clinical evaluation by the physician, there is no neurodevelopmental disorder, and the Autism Behavior Checklist (ABC) score is less than 30 points; (3) Children with normal intellectual development who require cerebrospinal fluid puncture for examination, such as spinal muscular atrophy, hydrocephalus, epilepsy, etc. (4) No direct relatives of ASD; (5) Evidence of a subject (or a legal representative) signed and dated informed consent document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study and are willing to participate in it.
Exclusion criteria
Exclusion criteria: 1. ASD group (1) Individuals with schizophrenia in children and adolescents, selective mutism, specific sensory language disorders, hearing or visual impairments; (2) Individuals with diseases such as Rett syndrome and fragile X syndrome that may manifest as ASD; (3) Individuals with cerebral palsy, epilepsy, and severe organ diseases (such as hepatitis, encephalitis, congenital malformations, etc.). 2. Control group Individuals with cerebral palsy or severe organ diseases (such as hepatitis, encephalitis, congenital malformations, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurotransmitter; | — |
Secondary
| Measure | Time frame |
|---|---|
| Protein; | — |
Countries
China
Contacts
Public ContactXingrong Song
Guangzhou Women and Children's Medical Center
Outcome results
None listed