lung transplantation
Conditions
Interventions
inspiratory muscle training + the standard pulmonary rehabilitation group:Inspiratory muscle training was performed using a cycler lung function tester. The intensity of the training started from 30%
the standard pulmonary rehabilitation group:1 Abdominal breathing training:Verbal education and instruction training, 15 repetitions per group, then rest for 2-3 minutes, 3 groups in total. The p
Sponsors
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Patients successfully completed lung transplantation, and extracorporeal membrane lung oxygenation (ECMO) and ventilator were withdrawn within one week; ? Age greater than 18 years old; ? Vital signs are stable - systolic blood pressure 90-180mmHg, mean arterial pressure: 65-110mmHg; heart rate: 40-120 beats/min; no new cardiac arrhythmia and myocardial ischemia; no signs of shock accompanied by blood lactic acid, >4mmolFL; no new unstable deep vein thrombosis and pulmonary embolism; no suspected aortic stenosis; inhaled oxygen concentration ( FiO2): =0.6; blood oxygen saturation (SpO2): >90%; respiratory rate: =40 breaths/min; no severe underlying hepatic or renal disease or new-onset progressive exacerbation of hepatic or renal impairment; no active bleeding; body temperature =38.5°C; RASS score of 0, and can be cooperated with rehabilitation training; ? Normal cognitive function and negative CAM- ICU. ? Patients or family members who were willing to sign the informed consent and participate in the study.
Exclusion criteria
Exclusion criteria: ? Patients who have been mechanically ventilated for more than one week; ? Severe anastomotic complications; ? Those who cannot properly cooperate with the treatment; ? New pulmonary embolism, lower extremity deep vein thrombosis and other complications; ? Those with severe mental or cognitive disorders; ? Patients who have received multi-organ transplantation and re-transplantation; ? Patients with complete damage to the phrenic nerve; (8) Patients who are unwilling or unable to provide written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal inspiratory pressure(MIP); | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum Expiratory Pressure(MEP);Forced vital capacity(FVC);Forced expiratory volume in one second(FEV1);Diaphragm thickness(DT);Diaphragm excursion(DE);Six minute walking distance(6MWD);Postoperative complication; | — |
Countries
China
Contacts
Public ContactMengyue Feng
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University
Outcome results
None listed