hypertension
Conditions
Interventions
Experimental group:Use of low-dose esketamine (0.2 mg/kg intravenously) for anesthesia induction
Control group:Anesthesia induction without the use of low-dose esketamine (use the same volume of normal saline as the experimental group)
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 65-80 with a history of hypertension and good control who are going to undergo tracheal intubation and general anesthesia surgery, regardless of gender; 2.The ASA level is II to III; 18kg/m^2=BMI=28kg/m^2; 3.Those who have good cognitive function during the screening period and can communicate and cooperate normally; 4.Those who voluntarily sign the informed consent form; 5.Those who plan to remove the endotracheal tube and return to the ward after the operation.
Exclusion criteria
Exclusion criteria: 1.Patients with poorly controlled or untreated hypertension (SBP>180mmHg or DBP>110mmHg), congestive heart failure, severe cardiac arrhythmia, unstable angina, recent (within 6 months) myocardial infarction, or cerebrovascular events. 2.Patients with severe obesity (BMI >40), Modified Mallampati Score 4, or known to have a severely difficult airway. 3.Patients with a history of previous neurological diseases such as epilepsy, Parkinson's, etc., severe impairment of consciousness, or psychiatric diseases such as major depression, schizophrenia, bipolar abnormalities, mental confusion, etc; 4.Patients with severe hepatic insufficiency or decompensation (Child-Pugh classification of grade C), severe renal insufficiency, or uremia (greater than CKD4 stage); 5.Those with a history of analgesic and alcohol abuse in the past; 6.Those who are allergic to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma catecholamines;Plasma cortisol;Postoperative adverse events;Postoperative recovery quality;Hemodynamic parameters at T0-T5; | — |
Countries
China
Contacts
Public ContactSun Yi
Guangdong Provincial People's Hospital
Outcome results
None listed