Postoperative Neurocognitive Dysfunction
Conditions
Interventions
non-POD/delayed neurocognitive recovery group:none
POD/delayed neurocognitive recovery group:none
non-PNCD group (data will be collected when patients come back for review):none
PNCD group (data will be collected when patients come back for review):none
PNCD testing group (newly recruited patients for improving reproducibility):none
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 99 Years
Inclusion criteria
Inclusion criteria: The study is divided into three section, and the patient will be recruited from the year of January 1, 2024 to December 31, 2024; January 1, 2025 to December 31, 2025; and January 1, 2026 to December 31, 2026. The rest of the criteria is: a) Patients aged over 60 years old who were scheduled to undergo general anesthesia surgery at the Department of Neurosurgery, Xuanwu Hospital, Capital Medical University ; b) Type of surgery: lumbar fusion/cervical fusion surgery; intraspinal tumor resection surgery; subtentorial hernia of cerebellum and other spinal surgery for curing diseases; c) 18kg/m2=BMI=30kg/m2; d) Right-handed.
Exclusion criteria
Exclusion criteria: a) Those who have contraindications to nuclear magnetic resonance scanning or cannot cooperate with nuclear magnetic resonance scanning; b) Those who have intracranial lesions or systemic complications; c) Those who have a history of neurological or psychiatric disorders or a history of abnormal brain structure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Connectivity (FC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Confusion Assessment Method (CAM) scale score;Montreal Cognitive Assessment (MoCA) scale score;Mini-mental State Examination (MMSE) scale score;auditory verbal learning test (AVLT);ADL ;Clinical Dementia Scales (CDR);Clock Drawing Task (CDT);Shape Trails Test B (STT-B) and Trail Making Test B (TMT-B);Hamilton Depression Scale (HAMD);Hamilton Anxiety Scale (HAMA);Hachinski Ischemia Scale;Fluency Test; | — |
Countries
China
Contacts
Public ContactLiu Yang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed