Periprosthetic joint infection
Conditions
Interventions
Infection group: Joint puncture to extract joint fluid:None
None infection group: Joint puncture to extract joint fluid:None
Sponsors
The first affliated hospital, Xinjiang medical university
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years old, gender is not limited; (2) The experimental group met the diagnostic criteria of chronic periprosthesis infection after joint replacement according to the 2018 Musculoskeletal Infection Association; The control group was eligible for primary replacement patients who excluded periprosthesis infection. (3) Voluntary and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with immune-related arthritis such as rheumatoid and rheumatism were excluded; (2) Radiotherapy and chemotherapy are required due to neoplastic diseases; (3) Receiving systemic glucocorticoid therapy (prednisone > 10mg/ day or equivalent hormone medication); (4) Severe immunodeficiency diseases (such as stage 3 HIV, sickle cell anemia, splenectomy, etc.); (5) Have a history of drug abuse; (6) Use immunosuppressive drugs to treat bone marrow or other transplants; (7) Pregnant, parturient and lactating women; (8) Participating in other clinical trials; (9) Researchers consider other reasons not appropriate for clinical trial participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint fluid target protein detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| X-ray;Hip and knee function score;Liver function;Kidney function;Erythrocyte sedimentation rate (ESR);C-reactive protein (CRP);Synovial fluid white blood cell count (WBC);Synovial fluid polymorphycyte neuclear cell (PMN)%;Doppler lower extremity vascular color ultrasound;Infection control rate;Time between infection recurrence;Re-operation rate;Type of antibiotic; | — |
Countries
China
Contacts
Public ContactBoyong Xu
Department of Joint Surgery, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People 's Republic of China
Outcome results
None listed