Patients undergoing endotracheal intubation under general anesthesia for spinal surgery
Conditions
Interventions
Control group:5 ml of 0.9% sodium chloride solution, inhalation for 15 minutes, 30 minutes before induction of anesthesia atomized
Experimental group:2ml of 25 mg/ml Esketamine solution and 3ml of 0.9% sodium chloride solution, nhalation for 15 minutes, 30 minutes before induction of anesthesia atomized
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-65 years who underwent elective general anesthesia for tracheal intubation spinal surgery in our hospital; ASA grade ?-?; Volunteer and sign informed consent.
Exclusion criteria
Exclusion criteria: Exclude people with cognitive impairment; Allergic to esketamine or combined with increased intracranial pressure and intraocular pressure; History of hyperthyroidism; Patients with poorly controlled or untreated hypertension (resting SBP over 180 mmHg, DBP over 100 mmHg); Combined with severe cardiovascular disease; Severe respiratory disease, throat disease; Abnormal lung function; A recent history of opioid use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of choking; | — |
Secondary
| Measure | Time frame |
|---|---|
| Waking agitation level;Ramsay sedation score;Post-operative sore throat; Hoarseness of voice;The satisfaction of patients;Incidence of pulmonary complications;Length of stay in PACU;extubation time;Total length of hospital stay;Postoperative hospital stay;Total medical expenses;Common adverse reactions;Systolic blood pressure;Diastolic blood pressure;Mean arterial pressure;Heart rate; | — |
Countries
China
Contacts
Public ContactMei Bin
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed