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The role and molecular mechanisms of Thrsp in NASH progression

The role and molecular mechanisms of Thrsp in NASH progression

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400086795
Enrollment
Unknown
Registered
2024-07-11
Start date
2024-07-12
Completion date
Unknown
Last updated
2024-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NAFLD

Interventions

NAFL(n=5):None
NASH(n=5):None

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: NAFL is defined as early simple steatosis (nonalcoholic fatty liver, NAFL, with >5% triglycerides in hepatocytes) in the absence of excessive alcohol consumption (<30 grams per day in men and <20 grams per day in women), other diseases affecting liver function such as viral infections, and pregnancy. In the absence of excessive alcohol consumption, other diseases affecting liver function such as viral infections, and pregnancy, the more advanced form is non-alcoholic steatohepatitis (NASH), which is mainly characterized by inflammation, swelling of hepatocytes (ballooning) with varying degrees of fibrosis in addition to lipids.

Exclusion criteria

Exclusion criteria: Excessive alcohol consumption (>30 grams per day in men and >20 grams per day in women), other diseases affecting liver function such as viral infections, and pregnancy.

Design outcomes

Primary

MeasureTime frame
The protein level of THRSP;

Secondary

MeasureTime frame
General information;

Countries

China

Contacts

Public ContactXu Xu

Shanghai Sixth People's Hospital

805582896@qq.com+86 131 4812 1812

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026