intestinal polyp
Conditions
Interventions
Propofol group:Induce anesthesia with 1.5mg/kg propofol, adding 0.5mg/kg propofol each time until the subject's MOAA/S score is = 1
Low dose Remimazolam group:0.05mg/kg remimazolam combined with 0.5mg/kg propofol anesthesia induction, with each additional 0.5mg/kg propofol added until the subject's MOAA/S score is = 1
Medium dose Remimazolam group:0.1mg/kg remimazolam combined with 0.5mg/kg propofol anesthesia induction, with each additional 0.5mg/kg propofol added until the subject's MOAA/S score is = 1
High dose Remimazolam group:0.15mg/kg remimazolam combined with 0.5mg/kg propofol anesthesia induction, with each additional 0.5mg/kg propofol added until the subject's MOAA/S score is = 1
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. All patients who are willing to receive sedation/anesthesia through digestive endoscopy for diagnosis and treatment needs. 2. Age = 65 years old. 3. ASA grade I to III patients. 4. 18 = BMI = 30kg/m ². 5. Mentally normal and able to communicate normally. 6. Clearly understand, voluntarily participate in the study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Complex surgery requires endoscopic diagnostic and therapeutic techniques (such as endoscopic mucosal resection, endoscopic submucosal dissection, etc.). 2. Patients who require intubation for airway management. 3. Diseases of the circulatory and respiratory systems that may threaten life if not properly controlled. 4. Allergies or contraindications to sedative/anesthetic drugs. 5. Identify patients with difficult airways. 6. Have a history of drug abuse and/or alcoholism. 7. Severe neurological disorders (such as stroke, hemiplegia, convulsions, epilepsy, etc.). 8. I have participated in clinical trials of other drugs as a subject in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension (mean arterial pressure decreased by = 25% from baseline or systolic blood pressure = 90mmHg); | — |
Secondary
| Measure | Time frame |
|---|---|
| Low oxygen incidence rate (SpO2 = 90);Duration of anesthesia induction;Endoscopic operation duration;Awakening time;Anesthesia induction and maintenance of additional medication frequency;Postoperative adverse events;Patient satisfaction;The magnitude of blood pressure drop; | — |
Countries
China
Contacts
Public ContactXuan Zhao
Shanghai Tenth People's Hospital
Outcome results
None listed