None listed
Conditions
Interventions
Normal Diet Group (100% Energy):Provide balanced meals that meet the daily total energy expenditure (100% of baseline TEE) throughout the experimental period.
16+8 diet group (100% energy):Provide balanced meals that meet the daily total energy expenditure (100% of baseline TEE) throughout the experimental period, with eating restricted to an 8-hour window
16+8 diet group (75% energy):Provide balanced meals that meet 75% of the baseline total energy expenditure (75% of baseline TEE) throughout the experimental period, with eating restricted to an 8-hour
Alternate-day fasting group (75% energy): Alternate between fasting and eating days (1 day eating + 1 day fasting). On eating days, participants consume approximately 125% of baseline TEE across three
5+2 diet group (75% energy):Each week consists of 5 days of eating and 2 consecutive fasting days. On eating days, provide meals that meet 95% of the baseline total energy expenditure (95% of baseline
Low-calorie diet group (75% energy):Provide balanced meals that meet 75% of the baseline total energy expenditure (75% of baseline TEE) throughout the experimental period, with a consistent reduction
Very low-calorie diet group (45% energy):Provide balanced meals that meet 45% of the baseline total energy expenditure (45% of baseline TEE) throughout the experimental period, with a significant redu
Sponsors
Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 35 years. (2) BMI between 18.5 and 24.0. (3) Willing to sign the informed consent form and cooperate with the trial grouping and implementation.
Exclusion criteria
Exclusion criteria: (1) Suffering from metabolic diseases such as hypertension, diabetes, and hyperlipidemia; (2) Suffering from uncontrollable mental illnesses; (3) Suffering from severe underlying diseases (e.g., renal failure, heart failure, cancer); (4) Currently taking medications that may affect study results (e.g., antihypertensives, antidiabetics, lipid-lowering drugs); (5) Perimenopausal or with irregular menstrual cycles; (6) Pregnant women; (7) Currently smoking; (8) Experiencing weight instability in the past three months (fluctuations of more than 4kg).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood proteome;Blood metabolome;Transcriptome;Fecal metagenome;DNA methylation;Fecal metabolome;Visceral Fat Area; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight;Waist circumference;Hip circumference;Waist-to-hip ratio;Blood pressure;Blood lipids;Inflammatory markers;Liver function;Kidney function;Basal metabolic rate;Body composition indicators; | — |
Countries
China
Contacts
Public ContactWang Hui
Shanghai Jiao Tong University School of Medicine
Outcome results
None listed