Chemotherapy-induced alopecia
Conditions
Interventions
Minoxidil combined with low level laser therapy group :Topical application of 5% minoxidil 1 ml topically once a day, plus 20 minutes of light once every two days using a low level laser cap.
Minoxidil group :Topical application of 5% minoxidil 1 ml topically once a day
Placebo control group:Topical application of placebo 1 ml topically once a day
Health group:No treatment
Sponsors
Affiliated Hospital of Yanbian University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Healthy people inclusion criteria: 1.Female who are aged 18-45 years, in generally good health. 2.Fully informed about and agreeing to the follicular unit extraction program, willing to participate voluntarily, and providing signed written informed consent. Patients inclusion criteria: 1.Female patients who are aged 18-45 years 2.Female patients who had undergone surgery for primary breast carcinoma 3.Breast cancer patients who are preparing to receive adjuvant chemotherapy (Paclitaxel as the primary drug) 4.Female patients who have a Kamofsky performance status greater than 90 5.No topical hair growth medications or other topical treatments within 3 months prior to treatment 6.No systematic use of drugs with hair regrowth effects in the 3 months prior to treatment 7.Patients who have good compliance and can participate in regular follow-up visits
Exclusion criteria
Exclusion criteria: Healthy people exclusion criteria: 1.Patients with serious diseases such as cancer. 2.Female patients who are pregnant or lactating who are in menopausalwho are with menstrual disorders 3.Patients who have inflammation or trauma of the scalp and other conditions that are not suitable for harvesting hair follicles 4.Patients who have other types of hair loss such as alopecia areata, androgenetic alopecia, telogen effluvium, and tinea capitis 5.Patients who is accompanied by other serious illnesses such as infections, and psychiatric symptoms. 6.Those whom the researcher considers unsuitable to participate in this study. Patients exclusion criteria: 1.Female patients with metastatic breast cancer 2.Female patients who are pregnant or lactating who are in menopausalwho are with menstrual disorders 3.Patients who have inflammation or trauma of the scalp and other conditions that are not suitable for harvesting hair follicles 4.Patients who have other types of hair loss such as alopecia areata, androgenetic alopecia, telogen effluvium, and tinea capitis 5.Patients who is accompanied by other serious illnesses such as infections, and psychiatric symptoms. 6.Patients who are participating in other clinical trial studies. 7.Those whom the researcher considers unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hair density and hair shaft diameter under dermoscope; | — |
Secondary
| Measure | Time frame |
|---|---|
| 7-point global-assessment scale;Global photographs;Sinclair's score;Dermatology Life Quality Index ;Patients' satisfaction;Hair loss and regrowth time;Skin Barrier Index Detection ;Hair follicle microscopic characteristics; | — |
Countries
China
Contacts
Public ContactLongquan Pi
Affiliated Hospital of Yanbian University
Outcome results
None listed