Diseases of the elderly
Conditions
Interventions
remimazolam group1:Induction with 0.2 mg/kg remimazolam
remimazolam group2:Induction with 0.3 mg/kg remimazolam
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Age 65-85 years old, gender is not limited, and unilateral elective hip replacement is to be performed. (2) ASA class I-III, 18Kg/m2=BMI=28kg/m2. (3) No serious cardiopulmonary or cerebral disease, well-controlled hypertension, diabetes mellitus and coronary heart disease. (4) Understand the experiment and participate voluntarily
Exclusion criteria
Exclusion criteria: (1) Difficult airway, lung infection and acute stage of asthma (2) Severe arrhythmia (high atrioventricular block, severe bradycardia <55 beats/min, etc.), unstable angina pectoris, poorly controlled hypertension, diabetes mellitus, coronary heart disease (3) Allergy to remazolam, propofol, long-term application of narcotic analgesics, long-term use of non-steroidal anti-inflammatory drugs and sedative drugs, long-term alcohol dependence. (4) Patients with previous mental illness or disorders of consciousness (5) The presence of metabolic, endocrine diseases, serious liver and kidney function abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The plasma concentration of remimazolam at each time point;Various pharmacokinetic parameters;Dose-response relationship of remimazolam;Time for recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic effects of remimazolam;PSI at T0 (before induction of anesthesia), T1 (at the time of loss of consciousness), T2 (immediately before laryngeal mask placement), T3 (1 min after laryngeal mask placement), T4 (3 min after laryngeal mask placement), and T5 (10 min after laryngeal mask placement) were measured at each time point.;Time for Loss of consciousness;Duration when PSI<50; | — |
Countries
Chine
Contacts
Public ContactYanLing Zhang
The Second Xiangya Hospital of Central South University
Outcome results
None listed