Disorder of consciousness
Conditions
Interventions
tDCS and Music stimulation group:Transcranial direct current stimulation and music therapy are synergistic
tDCS and sham Music stimulation group:transcranial direct current stimulation, tDCS
sham tDCS and Music stimulation group:Music stimulation
sham tDCS and sham Music stimulation group:None(control group)
Sponsors
The second people's hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Obtain the consent of the subject's guardian, join the study and sign the informed consent form; 2. Stroke patients; 3. Stable vital signs (respiratory or hemodynamically stable) with no progression of neurological symptoms; 4. Patients aged 30-80 years; 5. Not using central stimulant stimulants; No use of sedatives or neuromuscular blockers within 24 hours; 6. No history of epilepsy or other serious neurological and systemic diseases; 7. No contraindications to tDCS treatment ; 8 Right hand; 9. No contraindications to magnetic resonance examination.
Exclusion criteria
Exclusion criteria: 1. The condition changes, life-threatening, and the condition is unstable; 2. There are contraindications to MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revisions(CRS-R) score ;Functional connectivity coefficient between DMN, execution control network, and key nodes of the auditory network; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain-gut axis related biomarkers;Gut microbiome; | — |
Countries
China
Contacts
Public ContactJingpu Zhao
The second people's hospital of Shenzhen
Outcome results
None listed