Sufentanil-induced cough
Conditions
Interventions
Remazolam group (group R):Pretreating with 0.02mg/kg (5ml) remazolam before induction of general anesthesia
Control group:Pretreating with 5ml of saline before induction of general anesthesia
Sponsors
The People's Hospital of Chaozhou City
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Select 106 patients undergoing elective gynecologic surgery under general anesthesia at the People's Hospital of Chaozhou City from July 2024 to February 2025.The American Association of Anesthesiologists (ASA) grade I-II, aged 18-60 years old, BMI 18~30 kg/m2.
Exclusion criteria
Exclusion criteria: ? Patients preexisting severe cardiovascular, brain, lung, liver, kidney or nervous system diseases; ? Patients allergic to opioids, diazepines, and propofol; ? Patients suspiciously abusing or addicted to sedative or narcotic analgesic drug; ? History of smoking, asthma, or chronic cough; ? History of upper respiratory tract infection 2 weeks before surgery; ? Patients receiving angiotensin-converting enzyme inhibitors, bronchodilators, or steroids 2 weeks before surgery; ? Patients with modified Mallampati rating IV or predicted respiratory difficulties;Patients with modified Mallampati rating IV or predicted respiratory difficulties; ? Serious treatment-related complications unrelated to drug trials occurring during the treatment of patients, including massive bleeding that difficult to treat, death and so on; ? Patients participating in other drug trials 3 months before surgery; ? Patients refusing cooperate or asking to withdraw from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Pulse oxygen saturation;Heart rate; | — |
Countries
China
Contacts
Public ContactYe Haoling
The People's Hospital of Chaozhou City
Outcome results
None listed