Emergence agitation
Conditions
Interventions
Dexmedetomidine group (DEX group):Patients in the Dex group will receive dexmedetomidine nasal spray 100µg before induction
Normal saline group (NS group):Patients in the NS group will receive normal saline placebo before induction
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Aged >= 18 years old with American Society of Anesthesiologists (ASA) physical status I–III and scheduled for ENT surgery under general anesthesia
Exclusion criteria
Exclusion criteria: (1) neuropsychiatric disorders or a history of mental disorder, a Mini-Mental State Examination (MMSE) score < 15 (range from 0-30, with higher scores indicating better cognitive function); (2) left ventricular ejection fraction < 40%, second-degree or higher atrioventricular block without a pacemaker, sick sinus syndrome, or severe bradycardia (heart rate [HR] < 50 beats/min); (3) allergy to any medication used in this study; (4) refused to be enrolled.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of emergence agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The maximal SAS score;The incidence of emergence agitation in PACU;NRS (at rest and when coughing);The incidence of postoperative delirium;Postoperative sleep quality;The incidence of postoperative anxiety ; | — |
Countries
China
Contacts
Public ContactPeng Ke
Department of Anesthesiology, The First Affiliated Hospital of Soochow University
Outcome results
None listed