Heart valve disease, Coronary heart disease
Conditions
Interventions
the intervention group:During anesthesia induction, the experimental group was given a 1 mg/kg loading dose bolus, and a maintenance dose pump of 1% lidocaine, 2 mg·kg-1·h-1, was administered during t
the control group:During anesthesia induction, the control group was given a 0.1ml/kg loading dose bolus, and both groups were given a maintenance dose pump of 0.9% normal saline, 0.2 ml·kg-1·h-1 duri
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Signed informed consent (2) Elective cardiopulmonary bypass cardiac surgery, including heart valve replacement and coronary artery bypass (3) Age: 18-75 years old (4) The proposed anesthesia method is endotracheal intubation and general anesthesia
Exclusion criteria
Exclusion criteria: (1) Emergency surgery (2) previous cardiac surgery (3) Patients with known pre-existing hemolytic diseases, known coagulation system diseases, chronic inflammatory diseases, and liver dysfunction (4) Those who are allergic to lidocaine (5) Patients with NYHA Class IV cardiac function (6) Patients with severe arrhythmia in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Syndecan-1, HS, HPSE activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6, TNF-a, ostoperative blood loss 24 h, total postoperative blood loss, extubation time after operation, length of hospital stay, and other systemic complications; | — |
Countries
China
Contacts
Public ContactWeijian Wang
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed