Mild cognitive impairment
Conditions
Interventions
control group:Conventional cognitive intervention
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. The 2006 MCI International Working Group and the 2008 Clinical Research Guidelines for Mild Cognitive Impairment in China (? Cognitive complaints from patients and/or family members; ? Patients and/or informants reporting a relative decline in cognitive function over the past year; ? Cognitive impairment confirmed by clinical evaluation, manifested as impairment in memory and/or other cognitive domains; ? Preservation of daily life activities, complex instrumental functions not impaired or only very mild impairment; ? No dementia); 2. Age range from 50 to 85 years old; 3. 8 = HAMD-17 = 24 points; 4. Clinical Dementia Rating Scale (CDR) 0.5 points; 5. No contraindications for functional magnetic resonance imaging and able to cooperate in completing the examination; 6. Capable of cooperating in completing all training programs and including neuropsychological tests; 7. Agree to participate in this clinical trial and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are paramagnetic metal implants such as heart stents, pacemakers, dentures, and cochlear implants in the body; 2. Existence of intractable epilepsy, normal stress induced hydrocephalus, brain tumors and other neurological diseases; 3. Individuals diagnosed with mental retardation, bipolar disorder, schizophrenia, etc. by DSM-5 or ICD-10, or currently taking antipsychotic drugs; 4. Severe heart and lung diseases and liver and kidney dysfunction; 5. Severe visual and auditory dysfunction; 6. The researchers believe that participants who are not suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| auditory verbal learning test,AVLT; | — |
Secondary
| Measure | Time frame |
|---|---|
| WMS-RC;ERP;Resting state fMRI;Montreal Cognitive Assessment;Hamilton Depression Rating Scale,HAMD-17;Resting state alpha, beta, ?, and gamma waves of EEG;Functional near-infrared brain resting state data; | — |
Countries
China
Contacts
Public ContactLu Xiao
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed