None listed
Conditions
Interventions
Group B:Postoperative analgesia: Intravenous oliceridine 1.5 mg loading dose, 10 minutes later connected to an intravenous analgesic pump 0.3 mg/Kg oliceridine with normal saline to 100 ml at a rate
Group D:Postoperative analgesia: Intravenous morphine 4 mg loading dose, 10 minutes later connected to an intravenous analgesic pump 1 mg/Kg morphine with normal saline to 100 ml at a rate of 2 ml/h.
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) patients undergoing elective total laparoscopic hysterectomy; 2) ASA classification I-III; 3) Age 18-60 years old; 4) BMI 18-28Kg/m^2 and weight >40Kg; (5) Patients voluntarily accepted this trial and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) severe cardiac, pulmonary, hepatic and renal dysfunction 2) History of psychiatric illness or chronic use of psychotropic drugs (dementia, schizophrenia), chronic analgesic drugs, alcohol abuse 3) Patients with severe infections 4) Patients with brain dysfunction such as speech communication, hearing impairment or stroke, who are unable to communicate. 5) Pre-operative PaO2<60 mmHg or SpO2<92%. 6) Participation in a clinical study of another drug within the last 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting and exercise VAS pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative adverse events;Hemodynamic parameters; | — |
Countries
China
Contacts
Public ContactDuan Jinjuan
Anqing Municipal Hospital
Outcome results
None listed