Sarcopenia
Conditions
Interventions
Control group:health education
RT group:Low-intensity resistance exercise
RT+BFR group:Low-intensity resistance exercise combined with blood flow restriction
RT+rTMS group:Low-intensity resistance exercise combined with high-frequency repetitive transcranial magnetic stimulation
RT+BFR+rTMS group:Low-intensity flow-restricted resistance exercise combined with high-frequency repetitive transcranial magnetic stimulation
Sponsors
Shanghai University of Sport
Eligibility
Sex/Gender
Female
Age
50 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) age 50-65 years old; (2) natural menopause for more than 1 year (amenorrhea for 12 months without any obvious pathological or physiological cause can be judged as natural menopause); (3) right-handed (4) Irregular exercise (Exercise less than 3 times a week for less than 30 minutes for the past 3 months)
Exclusion criteria
Exclusion criteria: (1) a history of major surgery or fracture within 6 months before the study;(2) with exercise contraindications (such as severe cardiovascular disease, severe osteoporosis, neurological dysfunction, menopausal syndrome) and metal residues (including pacemakers, dentures, etc.);(3) patients receiving hormone therapy;(4) Unable to understand and complete the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle thickness,MT;Muscle cross-sectional area,CSA;Motor cortex excitability;Surface electromyograph,sEMG;Physical function;Muscle oxygen; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-terminal agrin fragment,CAF;Insulin-like growth factor;Growth hormone;Total testosterone;estradiol; | — |
Countries
China
Contacts
Public ContactJie Zhuang
Shanghai University of Sport
Outcome results
None listed