postoperative nausea and vomiting
Conditions
Interventions
Intervention group:Application of ondansetron 15min before induction of anaesthesia
Control group:Intravenous ondansetron infusion at the end of surgery
Sponsors
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Subjects >18 years of age participating in the trial 2. ASA classification I-III with 3-4 PONV risk factors in Apfel score. 3. General anesthesia proposed. 4. No major respiratory or circulatory diseases and no significant abnormalities in liver or kidney function. 5. The patients and their families were fully informed about the study, enrolled voluntarily and were able to co-operate with this study.
Exclusion criteria
Exclusion criteria: 1. Recent use of antiemetic medication 2. People with mental illness who have recently taken relevant medication 3. Allergy to ondansetron 4. Pregnant or breastfeeding 5. QT interval >450ms or with tip-twist tachycardia 6. Patients with severe cardiovascular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting 0-24h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea 0-6h, 0-24h, 24-48h;Nausea severity in patients with nausea only 0-6h, 0-24h, 24-48h postoperatively;Incidence of postoperative vomiting 0-6h, 0-24h, 24-48h; | — |
Countries
China
Contacts
Public ContactChi Yongliang
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Outcome results
None listed