severe rebound pain
Conditions
Interventions
Acetaminophen group :500mg of acetaminophen injection was administered at the end of surgery and 6 hours postoperatively, respectively
saline group:Administer the same volume of normal saline at the same time
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1)Patients between 18 and 60 yr of age. (2)Patients undergoing elective arthroscopic knee surgery under spinal anesthesia. (3)ASA I–III. (4)Voluntarily participate in this study and sign a written informed consent form
Exclusion criteria
Exclusion criteria: (1) Allergy to acetaminophen; (2) Liver function impairment is defined as levels of alanine aminotransferase and/or aspartate aminotransferase exceeding the upper limit of the normal range by more than 2 times, or total bilirubin being at least 1.5 times the upper limit of the normal range; (3) Renal insufficiency, defined as creatinine range>176umol/L; (4) Uncontrolled hypertension or diabetes; (5) Other situations determined by the researcher to be unsuitable for selection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of rebound pain within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score;Duration of nerve block;Use of analgesic drugs;QoR-15 rating;sleep quality; | — |
Countries
China
Contacts
Public ContactRili Yu; Liao Qin
The Third Xiangya Hospital of Central South University
Outcome results
None listed