refractory wounds
Conditions
Interventions
Control group:The wound is partially debrided, dress the wound with sterile gauze and change the dressing the next day
Sponsors
department of Orthopedic surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) 18-90 years old 2) Leg ulcers, which can be caused by any of the following: diabetes, venous insufficiency, trauma, surgery, and pressure 3) The wound area > 0.5 cm2 4) There was no trend towards healing after 4 weeks of regular treatment 5) Voluntarily participate in this study, and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1) Active cellulitis 2) osteomyelitis 3) gangrene 4) ABI 1.3 5) Revascularization was performed in the last 6 weeks(Ipsilateral lower extremity) 6) Taken any experimental drug or applied topically to the wound 4 weeks prior to the study 7) Presence of significant medical conditions that would impair wound healing, such as aplastic anemia, liver disease, scleroderma, malignancy, or immunosuppressive therapy 8) Patients who are participating in other clinical trials 9) Specimen collection was not satisfactory 10) Vulnerable groups, including people with mental illness, cognitive impairment, critically ill patients, minors, pregnant women, etc. 11) Other reasons that are considered unsuitable by the investigators to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| wound area;immunofluorescence; | — |
Secondary
| Measure | Time frame |
|---|---|
| RNA sequence; | — |
Countries
China
Contacts
Public Contactxianfeng lin
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed