sepsis
Conditions
Interventions
Study Group:partially hydrolyzed guar gum, PHGG 10g bid + enteral nutrtion
Control Group:Enteral nutrition with equivalent caloric and nitrogen content.
Sponsors
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) 18-80 years old; 2) Sepsis was defined as a suspected or proven infection, in combination with a Sequential Organ Failure Assessment (SOFA) score at admission of =2, concordant with the sepsis-3 definitions; 3) Patients who had an expected minimum length of hospital stay of 72h.
Exclusion criteria
Exclusion criteria: 1) general contraindications for enteral nutrition, eg. short bowel syndrome, without pathway for enteral nutrition; 2) uncompensated hemodynamic failure of any origin, norepinephrine =0.3ug/kg/min or equivalent dose vasoactive agent or blood lactate =4mmol/L; 3) moderate to severe liver dysfunction; 4) pregnancy; 5) The expected survival time is less than 7 days eg. end-stage malignancy, CPR was performed 7 days prior to the study; 6) Plant survival state.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence rate of nosocomial infection;Targeted feeding rate;Changes of albumin, prealbumin, blood lipid, blood glucose;serum CRP, PCT, IL-6;CD4/CD8,CD19,HLA-DR;ventilation free day;length of ICU stay;length of hospital stay;ICU mortality;28 day all-cause mortality; | — |
Countries
China
Contacts
Public ContactHua Zhou
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Outcome results
None listed