Comparison of the safety and efficacy of oxaliplatin fumarate and sufentanil combined with propofol in anesthesia for ERCP surgery

Comparison of the safety and efficacy of oxaliplatin fumarate and sufentanil combined with propofol in anesthesia for ERCP surgery - Comparison of the safety and efficacy of oxaliplatin fumarate and sufentanil combined with propofol in anesthesia for ERCP surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400086623

Enrollment

Unknown

Registered

2024-07-08

Start date

2024-07-10

Completion date

Unknown

Last updated

2024-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ERCP surgery

Interventions

Otellidine group:The patient is required to abstain from drinking for 2-4 hours and fast for 8 hours before surgery. After entering the room, their heart rate (HR), blood pressure (SBP/DBP), blood oxy

If BIS>60, add 0.5mg/kg of propofol every 3 minutes until the target BIS value is reached and surgery begins. And continuously administer 4-8mg ? kg-1 ? h-1 propofol, closely monitor the patients resp

If the SpO2 drops below 90% for more than 5 seconds, treatment such as mandibular support, nasopharyngeal ventilation, high flow assisted ve

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ? Patients aged 18-65, with a body mass index of 18.5-27.9kg/m2, ASA grade I-III, approved by the hospital ethics committee, fully aware of anesthesia and related risks, and signed an informed consent form for anesthesia; ? Surgical time = 120 minutes.

Exclusion criteria

Exclusion criteria: ? Clearly diagnose heart diseases (such as heart failure, angina, myocardial infarction, malignant arrhythmia, etc.); Clearly diagnose lung diseases (asthma, chronic obstructive pulmonary disease, pulmonary embolism, pulmonary edema, or lung cancer); Patients with central nervous system abnormalities; ? Patients who are allergic to opioid drugs and propofol, and those who do not cooperate or cannot communicate; ? Suspected patients with abuse and addiction to sedatives or anesthetic analgesics; ? Has a history of difficult airways or is expected to experience difficult airways (Mallampati = grade 3); ? Patients with severe liver dysfunction. ? Pregnant women. ? The expected surgical time is greater than 120 minutes.

Design outcomes

Primary

Measure	Time frame
The incidence of hypoxemia;	—

Secondary

Measure	Time frame
Vital signs;The incidence of nausea and vomiting;Incidence of body movement and coughing;Drug usage;Awakening time;OAA/S;VAS pain score;Surgeon satisfaction;	—

Countries

China

Contacts

Public ContactDeng Haibo

Huizhou Third People's Hospital

869150811@qq.com+86 137 2532 4556

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026