CKD-MBD
Conditions
Interventions
Experimental group:Alendronate sodium + calcitriol capsules
control group:calcitriol capsules
Sponsors
Xijing Hospital affiliated to Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Obtain written informed consent; 2. Age 18-80 years old; 3. Receiving maintenance peritoneal dialysis treatment for more than 6 months; 4. Meet the diagnostic criteria for CKD-MBD in the 2017 KDIGO Guidelines.
Exclusion criteria
Exclusion criteria: 1. Pre-treatment with bisphosphonates or other anti-bone resorption drugs in the past 6 months 2. Rule out hypodynamic bone disease according to biochemical indicators or bone biopsy; 3. History of parathyroidectomy; 4. History of hormone therapy in the past six months; 5. Severe malnutrition; 6. Active infection; 7. Complicated with serious heart, liver and lung diseases; 8. History of multiple myeloma or bone tumor; 9. Previous history of major upper digestive tract (GI) diseases, such as peptic ulcers and esophagus Inflammation or severe indigestion; 10. Plan to undergo invasive dental surgery during the study observation period; 11. The subject can stand or sit up for < 30 minutes; 12. Blood calcium < 2.1mmol/L; 13.PTH < 300pg/mL.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMD;bone metabolism indicators;The incidence of new fractures (non vertebral fractures and clinical vertebral fractures) within 18 months; | — |
Countries
China
Contacts
Public ContactLijie He
Xijing Hospital affiliated to Air Force Medical University
Outcome results
None listed