High-grade glioma
Conditions
Interventions
Metronomic chemotherapy group:Temozolomide was given orally at a dose of 75mg/m2/d on the first day of radiotherapy, followed by adjuvant chemotherapy at a dose of 50mg/m2/d on the first day of radiot
Conventional chemotherapy group:For mo thiazole amine capsule, the day 1 to begin radiation oral 75 mg/m2 / d, until the end of radiotherapy, 28 days rest, began to adjuvant chemotherapy, adjuvant che
Sponsors
Affiliated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Histologically confirmed WHO II-IV gliomas and high-risk WHO II gliomas (with residual disease confirmed by imaging) without radiotherapy or chemotherapy; (2)KPS=70; (3) ECOG 2 or less; (4) Age of 18-70 years old, both sexes; ? White blood cell =4.00×10^9g/L, platelet =100×10^9g/L, hemoglobin =90g/L, total bilirubin, alanine aminotransferase, aspartate aminotransferase =1.5 times the upper limit of normal; (6) creatinine 1.5 times the upper limit of normal or less; (7) understand the study and have signed the informed consent;
Exclusion criteria
Exclusion criteria: (1) primary tumors underwent radiotherapy; (2) always had received a patients with vascular targeted therapy of epidermal growth factor; (3) during pregnancy or lactation. (4) serious lung or heart disease; (5) severe allergic history or specific constitution; (6) patients with personality or mental disorders, without or with limited capacity for civil conduct; (7) can't understand this experiment, rejection, or not to participate in the test of informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grade 3-4 hematological toxicity; | — |
Secondary
| Measure | Time frame |
|---|---|
| OVerall survival;Progress-free survival; | — |
Countries
China
Contacts
Public ContactFeng Jin
Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed