Poor ovarian response
Conditions
Interventions
Single arm:Recombinant Human Follitropin Alfa Solution for Injection (Gonal-f) : Recombinant Human Lutropin alfa for Injection (Luveris) 2:1
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: 1) Age =1.1 ng/ml and/or AFC >=5 ; 3)Conventional protocol (GnRH agonist long or GnRH antagonist protocol) in the first IVF/ICSI cycle ; 4) r-hFSH mono form COS day 1 to day 5, with or without hMG supplementary from day 6 to trigger day for the first cycle, and the starting dose of r-hFSH is determined by the patient's AMH or AFC; 5) Number of oocytes retrieved =18.5 kg/m^2 and BMI < 28 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Unconventional COS protocols (not GnRH agonist long or GnRH antagonist protocol) ; 2. Chromosomal abnormalities or single gene disorders ; 3. PGT cycles ; 4. Previous ovarian surgery ; 5. Patients with repeated implantation failure (3 or more transfers) ; 6. Repeated pregnancy loss patients (3 or more times).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of oocytes retrieved; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of MII oocytes (in ICSI subgroup only) MII(ICSI) Number of MII oocytes (in ICSI subgroup only) ;Total r-hFSH dose ;Normal fertilization rate;Good-quality embryo rate at day 3;Implantation rate;Clinical pregnancy rate;Ongoing pregnancy rate;Incidence and severity of AE, SAE, and OHSS; | — |
Countries
China
Contacts
Public ContactRong Li
Peking University Third Hospital
Outcome results
None listed