Patients undergoing general anesthesia
Conditions
Interventions
Intervention group (Induction of anesthesia with fospropofol at a dose of 10-20 mg/kg, and maintenance of anesthesia at a dose of 10-15 mg/kg/h.):None
Control group (Induction of anesthesia with propofol at a dose of 1.5-2.5 mg/kg, and maintenance of anesthesia at a dose of 4-10 mg/kg/h.):None
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1)Age = 18 years, gender not limited; (2)Patients scheduled for surgery under general anesthesia; (3)ASA classification I-II; (4)18 kg/m² = BMI = 30 kg/m²; (5)Able to understand the study procedures and communicate effectively with the research staff; (6)Voluntarily participate and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Individuals who have participated in other drug clinical trials within the past 3 months; (2) Individuals with incomplete clinical examination data or deemed unsuitable for this study by the researcher; (3) Individuals with communication barriers (language barriers, mental disorders); (4) Individuals with severe cardiovascular diseases such as atrioventricular block, severe cardiac dysfunction, or cerebral insufficiency; (5) Individuals known to have intolerance or allergy to the experimental drug used in this study; (6) Individuals with peripheral vascular diseases, recent use of antidepressants and hypnotics, or multiple surgical anesthesia experiences; (7) Individuals with a history of neurological disorders: craniocerebral injury, intracranial hypertension, cerebral aneurysm, or history of cerebrovascular accidents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs during the perioperative period;Patient questionnaire follow-up data; | — |
Countries
China
Contacts
Public ContactZhongyuan Xia
Renmin Hospital of Wuhan University
Outcome results
None listed