Oxaliplatin-related peripheral neurotoxicity
Conditions
Interventions
Group A:Oral alone
Group B:Hand-washing alone
Group C:Oral combined hand-washing
Group D:Oral Mecobalamin Tablets
Sponsors
Shanxi Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ?Patients who have been pathologically or cytologically confirmed as intestinal or gastric cancer; ? The age of the patients is 18-80 years old and gender is not limited; ? Patients with KPS = 60 points and expected survival period of not less than 3 months; ? Those who develop peripheral neurotoxicity after receiving oxaliplatin treatment; ? No major visceral organ dysfunction, no cardiovascular and cerebrovascular complications; ? All skin of the limbs is intact; (vii) Those who are accompanied by coldness and fear of cold, no warmth in the limbs; fatigue, qi deficiency; pale and fat tongue, or teeth marks, sunken and thin pulse, and other signs of yang deficiency. (viii) Voluntarily signing the informed consent form and joining this study.
Exclusion criteria
Exclusion criteria: (i) Previous neuropathy of any grade, such as a family history of hereditary/familial neuropathy, especially peripheral neuropathy; (ii) Prior use of paclitaxel; ? Uncontrolled diabetes mellitus, combined with diabetic foot; ? Those who are receiving carbamazepine, phenytoin sodium, valproate, gabapentin, pregabalin, venlafaxine, desvenlafaxine, milnacipran, duloxetine, tricyclic antidepressants; ? Participation in any other clinical study of Chinese or Western medicine for the prevention or treatment of neuropathy; ?Pregnant or lactating women; (vii) Those with a history of allergy to drug exposure or the presence of dermatological lesions of the hands and feet (e.g., eczema); (viii) Psychiatric patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EORTCQLQ-CIPN20; | — |
Secondary
| Measure | Time frame |
|---|---|
| EORTC QLQ-C30;KPS;Electromyography;Evaluation of toxicity and side effects; | — |
Countries
China
Contacts
Public ContactLi Xiaoli
Shanxi Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed