Kidney Cancer
Conditions
Interventions
Experimental group:Vorolanib combined with cadonilimab
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Subjects voluntarily participate in this study, willing and able to comply with and sign the informed consent form; 2) Histologically confirmed clear cell renal cell carcinoma; 3) Advanced (not suitable for curative surgery or radiation therapy) or metastatic (AJCC Stage IV) RCC; 4) No prior systemic treatment for RCC, except for the following situations: a) For completely resectable renal cell carcinoma, having received one type of adjuvant or neoadjuvant treatment, if the treatment does not include drugs targeting VEGF or VEGFR, and recurrence occurs at least 6 months after the last adjuvant or neoadjuvant treatment; 5) Confirmed to have at least one measurable lesion according to RECIST 1.1 criteria; 6) KPS score = 70; 7) Expected survival time of more than 3 months; 8) Aged 18-75 years; 9) Good function of major organs and sufficient hematology, meeting the following criteria: ? Absolute neutrophil count (ANC) = 1500 cells/µL (no granulocyte colony-stimulating factor support within 2 weeks before Cycle 1, Day 1) Platelet count (PLT) = 80 × 10^9/L. WBC count = 2500/µL without G-CSF, = 15000/µL Lymphocyte count = 500/µL Hemoglobin = 9.0 g/dL (Cycle 1), not dependent on erythropoietin, and no transfusion of concentrated red blood cells (pRBC) in the past 2 weeks Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) = 3 times the upper limit of normal (ULN) (liver metastasis = 5 times ULN). If the patient has bone metastasis, ALP = 5 times ULN. Serum bilirubin = 1.5 × ULN. Patients with known Gilbert's syndrome can be enrolled if serum bilirubin level = 3 times ULN. Serum albumin = 2.8 g/dL Creatinine = 2.0 × ULN or calculated creatinine clearance rate = 30 mL/min. Urine protein/creatinine ratio (UPCR) = 1 mg/mg (= 113.2 mg/mmol) 10) For women who are not menopausal (amenorrhea for 12 months) or surgically sterile (without ovaries and/or uterus): agree to use two appropriate methods of contraception, including at least one method with an annual failure rate of = 1%. 11) Sexually active subjects of childbearing potential and their partners must agree to use medically recognized contraceptive methods during the study and for 5 months after the last dose of study treatment for women and 7 months for men (e.g., barrier methods, including male condoms, female condoms, or diaphragms coated with spermicidal gel). 12) Female subjects of childbearing potential must not be pregnant at screening. Women of childbearing potential are defined as premenopausal women who can become pregnant (i.e., women who have had any menstrual signs in the past 12 months, except for those who are surgically sterile as mentioned above).However, women who have been amenorrheic for 12 months or longer are still considered to have childbearing potential if the amenorrhea is likely due to previous chemotherapy, anti-estrogens, low body weight, ovarian suppression, or other reasons.
Exclusion criteria
Exclusion criteria: 1) Received any systemic treatment for RCC, unless the investigator can provide evidence that the subject has been randomly assigned to the placebo group; 2) Central nervous system metastasis; 3) Active malignant tumor in the past 24 months (except for renal cell carcinoma, skin basal cell carcinoma or squamous cell carcinoma that has been clearly treated, as well as cervical or bladder carcinoma in situ). Participants with a history of localized and low-risk prostate cancer who have received curative treatment and have not had a prostate-specific antigen (PSA) recurrence in the past 5 years may participate in the study; 4) Received prior radiotherapy within 21 days before the start of study treatment (palliative radiotherapy for bone lesions is allowed, provided it is completed at least 2 weeks before the start of study treatment); 5) Currently participating in another study or received study drugs within 4 weeks before the start of study treatment. 6) Receiving live vaccines within 30 days after the planned start of study treatment (first cycle/day 1). Live vaccines include but are not limited to measles, mumps, rubella, varicella/zoster (chickenpox), yellow fever, rabies, BCG, and typhoid vaccines. Injectable seasonal influenza vaccines are generally inactivated virus vaccines and are allowed; however, intranasal influenza vaccines are attenuated live vaccines and are not allowed. 7) Participants with proteinuria > 1+ on urine dipstick test will undergo a 24-hour urine collection for quantitative assessment of proteinuria. Participants with urinary protein = 1g/24h will not be eligible. 8) Fasting total cholesterol > 300 mg/dL (or 7.75 mmol/L) and/or fasting triglyceride level 2.5 times the upper limit of normal (ULN). Note: These participants can be included after lipid-lowering treatment. 9) Uncontrolled diabetes defined as fasting blood glucose > 1.5 times the upper limit of normal. Note: These participants can be included after hypoglycemic treatment. 10) Uncontrolled hypercalcemia (= 1.5 mmol/L ionized calcium or Ca = 12 mg/dL or corrected serum calcium = ULN) or symptomatic hypercalcemia requiring continued bisphosphonate treatment or denosumab. 11) QTc interval prolongation to > 480 ms. 12) Participants who have not fully recovered from any toxicity and/or complications caused by major surgery before starting treatment. 13) Malabsorption, gastrointestinal anastomosis, or any other condition that may affect the absorption of study drugs. 14) Clinically significant hematuria, vomiting blood, or coughing up blood > 0.5 teaspoon (2.5 ml) within 12 weeks before the first dose, or other significant bleeding history (such as pulmonary hemorrhage). 15) Significant cardiovascular impairment within 12 months after the first dose of study drug: history of congestive heart failure New York Heart Association class II or higher, unstable angina, myocardial infarction, cerebrovascular accident, or arrhythmia related to hemodynamic instability. The following conditions are also excluded: left ventricular ejection fraction (LVEF) below the institutional normal range determined by gated blood pool scan or echocardiogram. 16) Active infection (any infection requiring systemic treatment). 17) Positive for human immunodeficiency virus (HIV). 18) Active hepatitis B or C. 19) Known history of interstitial lung disease or any evidence. 20) History of (non-infectious) pneumonia requiring steroids, or currently suffering from pneumonia. 21) Diagnosed w
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression Free Survival;Overall Survival;Disease Control Rate;12 months Progression Free Survival Rate;12 months Overall Survival Rate;24 months Overall Survival Rate;Safety;Health-related quality of life; | — |
Countries
China
Contacts
Public ContactXiongjun Ye
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed