birth defects
Conditions
Interventions
high risk pregnant woman:NA
General pregnant women:NA
Sponsors
Obstetrics & Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: The prospective cohort of general pregnant women will be defined as having a singleton pregnancy between 12 and 22+6 weeks of gestation, being over 20 years of age, and receiving a molecular diagnostic; for the cohort of high-risk pregnant women, enrollment will be defined as having a structural abnormality on ultrasound screening of the fetus, having a high risk on serologic prenatal screening, having a family history of hereditary disorders, or having other risk factors.
Exclusion criteria
Exclusion criteria: Exclusion criteria: (i) complications of other pregnancy complications; (ii) severe cardiac, hepatic and renal insufficiency; (iii) patients with autoimmune diseases and malignant neoplastic diseases. Pregnant women with abnormalities due to chromosomal, congenital anomalies, preterm birth and multiple pregnancies were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| specificity;Positive predictive value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactXu Chenming
The Obstetrics & Gynecology Hospital of Fudan University
Outcome results
None listed