parkinson's disease
Conditions
Interventions
Parkinson's disease with frozen gait group:None
Parkinson's disease without frozen gait group:None
Healthy Controls:None
M1 transcranial magnetic stimulation group for patients with frozen gait (control group 1):Received M1 with DLPFC pseudo rTMS: ? M1 rTMS (frequency of stimulation 10Hz-11:00 am)
? DLPFC pseudo M1 rTMS (intensity 5% of the treatment group at 15:00-17:00 p. m.) once daily for 10-14 days.
Clinical assessments will be performed regularly during treatment, including gait testing,
M1-DLPFC combined transcranial magnetic stimulation group for patients with frozen gait (combined stimulation group 1, treatment group 1):Received M1 with DLPFC rTMS: ?M1 rTMS (with stimulation at 10H
?DLPFC rTMS (at 1Hz from 15:00-17:00. pm) once daily for 10 to 14 days.
Clinical assessments will be performed regularly during treatment, including gait testing, motor function scores, and quality of
M1 transcranial magnetic stimulation group for patients without frozen gait (control group 2):Received M1 with DLPFC pseudo rTMS: ? M1 rTMS (frequency of stimulation 10Hz-11:00 am)
M1-DLPFC combined transcranial magnetic stimulation group for patients without frozen gait (combined stimulation group 2, treatment group 2):Received M1 with DLPFC rTMS: ?M1 rTMS (with stimulation at
?DLPFC rTMS (at 1Hz from 15:00-17:00. pm) once
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients with Parkinson's disease should meet the 2015 MDS Parkinson's disease; 2. Patients with Parkinson's syndrome should meet the diagnostic criteria for PDS, and data collection and follow-up; 3. Healthy subjects should have no cerebrovascular diseases, brain trauma, hydrocephalus, intracranial space occupation, serious mental illness or serious systemic diseases, or abnormal examination results.
Exclusion criteria
Exclusion criteria: Those with cerebrovascular disease, traumatic brain injury, hydrocephalus, intracranial occupancy, severe psychiatric disease, severe systemic disease, or abnormal test results, who are deemed unsuitable for enrollment after evaluation by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Timed Up and Go (TUG) Test;MDS Unified-Parkinson Disease Rating Scale, MDS-UPDRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Parkinson's Disease Quality of Life Questionnaire (PDQ-39);Parkinson's disease sleep scale, PDSS;Security Index;polysomnography, PSG;Minimum Mental State Examination;FOGQ;Hamilton Depression Scale, HAMD;Hamilton Anxiety Scale, HAMA; | — |
Countries
China
Contacts
Public ContactOumei Cheng
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed