amblyopia
Conditions
Interventions
Experimental group:4 weeks of rTMS treatment (6 times/week) was received in the East Ward of Zhengda First Affiliated Hospital. rTMS equipment: children's special 8-figure coil, frequency (10HZ), inte
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
6 Years to 17 Years
Inclusion criteria
Inclusion criteria: Children aged 6 to 17 years old with amblyopia diagnosed as monocular refractive amblyopia, binocular refractive amblyopia, monocular form deprivation amblyopia, binocular form deprivation amblyopia, and after receiving conventional amblyopia training treatment for more than 3 months, they stopped amblyopia training on their own or according to the doctor's advice, and the best corrected visual acuity did not improve, rebound or even decline after improvement in the last 3 months or longer. The best corrected visual acuity in amblyopic eyes is 0.15logMAR or worse 1. Monocular refractive amblyopia: the best corrected visual acuity in the affected eye is 0.15logMAR or worse, and the best corrected visual acuity in the opposite eye is better than 0.15logMAR The diopter difference of the hyperopic spherical mirror =1.50DS, or the diopter difference of the cylindrical mirror =1.00DC, or the hyperopic diopter of the affected eye =5.00DS and (or) astigmatism =2.00DC, to rule out strabismus, form deprivation and other causes of amblyopia. 2. Binocular refractive amblyopia: The best corrected visual acuity of both eyes was 0.15logMAR or worse, and the diopter difference of the binocular hyperopia was =1.50DS, or the diopter difference of the cylindrical mirror was =1.00DC, or the diopter of the binocular hyperopia was =5.00DS and/or the astigmatism was =2.00DC, excluding amblyopia caused by strabismus and form deprivation. 3. Monocular form deprivation amblyopia: the best corrected visual acuity of the affected eye is 0.15logMAR or worse, and the best corrected visual acuity of the opposite eye is better than 0.15logMAR. After diagnosis of congenital cataract and cataract extraction, amblyopia caused by strabismus and ametropia is excluded. 4. Binocular form deprivation amblyopia: the best corrected visual acuity in both eyes is 0.15logMAR or worse. After diagnosis of congenital cataract and cataract extraction, amblyopia caused by strabismus and ametropia is excluded.
Exclusion criteria
Exclusion criteria: 1. Patients with ocular trauma, ptosis and other eye diseases or hematopoietic system diseases, major organ dysfunction and other systemic organic diseases 2. Patients with contraindications for TMS, such as epilepsy, hearing impairment, increased intracranial pressure, and metal implants 3. Previous history of eye surgery (except congenital cataract extraction and intraocular lens implantation, strabismus correction)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity;Structural magnetic resonance, functional magnetic resonance image and signal waveform of brain region; | — |
Secondary
| Measure | Time frame |
|---|---|
| Naked vision;synoptometer;Four point lamp; | — |
Countries
China
Contacts
Public ContactGuangying Zheng
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed