Cardiac function
Conditions
Interventions
Study 1: control group:Supplementation with 18 g of placebo per day
Study1: low-dose group:Supplementation with 6 g of D-ribose + 12 g of placebo per day
Study 1: Medium-dose group:Supplementation with 12 g of D-ribose + 6 g of placebo per day
Study 1: high-dose group:Supplement with 18 gD-ribose daily
Study 2: Placebo group supplemented before exercise:Supplementation with 18 g of placebo 30 min before exercise
Study 2: Placebo supplementation was given before and during exercise:9 g of placebo was supplemented 30 minutes before exercise, and 3 g of placebo per 5 km during exercise for a total of 3 supplemen
Study 2: D-ribose group was supplemented before exercise:Supplement with 18 g of D-ribose 30 min before exercise
Study 2: D-ribose supplementation group before and during exercise:9 gD-ribose was supplemented 30 min before exercise, and 3 gD-ribose was supplemented every 5 km during exercise for a total of 3 tim
Sponsors
School of Human Sports Science, Beijing Sport University
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for studies 1 and 2 were as follows: ? Age 45-65 years old, 18.5= BMI <24; ? Have more than five years of experience in marathon sports, and run regularly more than 3 times a week; ?Have not taken any other supplements related to cardiovascular disease or sports nutrition in the three months prior to this study.
Exclusion criteria
Exclusion criteria: The exclusion criteria for both Study 1 and Study 2 were as follows: ? Have clear contraindications to exercise or other diseases that affect the exercise plan; ? Are taking D-ribose or related nutritional products containing D-ribose; ?expected to participate in a marathon during the intervention period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study 1 outcome measure:Maximal oxygen uptake;Study 1 outcome measure:Exhaustion of time;Study 1 outcome measure:Maximum heart rate during exercise;Study 1 outcome measure:Peak blood lactate;Study 1 outcome measure:Rate of lactate clearance;Study 1 outcome measure:Cardiac ultrasound;Study 1 outcome measure:Cardiac troponin;Study 1 outcome measure:Creatine kinase isoenzyme;Study 1 outcome measure:N-terminal B-type natriuretic peptide precursor;Study 1 outcome measure:Superoxide dismutase;Study 1 outcome measure:catalase;Study 1 outcome measure:Reduced glutathione;Study 1 outcome measure:Glutathione peroxidase;Study 1 outcome measure:Malondialdehyde;Study 1 outcome measure:lactate dehydrogenase;Study 1 outcome measure:creatine kinase;Study 1 outcome measure:myoglobin;Study 1 outcome measure:Time to complete the simulated half marathon;Study 1 outcome measure:Simulate the average heart rate after the race;Study 1 outcome measure:Simulated heart rate immediately after the competition;Study 1 outcome measure:Simulated heart rate 3min-15min after the race;Study 2 outcome measures:Peak blood lactate;Study 2 outcome measures:Rate of lactate clearance;Study 2 outcome measures:Cardiac ultrasound;Study 2 outcome measures:Cardiac troponin;Study 2 outcome measures:Creatine kinase isoenzyme;Study 2 outcome measures:N-terminal B-type natriuretic peptide precursor;Study 2 outcome measures:Time to complete the simulated half marathon;Study 2 outcome measures:Simulate the average heart rate after the race;Study 2 outcome measures:Simulated heart rate immediately after the competition;Study 2 outcome measures:Simulated heart rate 3min-15min after the race; | — |
Countries
China
Contacts
Public ContactGuo Xian
Beijing Sport University
Outcome results
None listed