The robot-assisted total knee arthroplasty
Conditions
Interventions
Intravenous administration group (utilizing a pneumatic tourniquet):Before making the skin incision, dissolve tranexamic acid (20mg/kg) in 100 ml of 0.9% sodium chloride for intravenous infusion (with
Intraosseous injection group (utilizing a tourniquet):After making the skin incision, drill into the medial side of the tibial tuberosity and the femoral medial condyle, reaching the cancellous bone.
Intravenous administration group (not using a tourniquet):Before making the skin incision, dissolve tranexamic acid (20mg/kg) in 100 ml of 0.9% sodium chloride for intravenous infusion (not using a to
Intraosseous injection group (not using a tourniquet):After making the skin incision, drill into the medial side of the tibial tuberosity and the femoral medial condyle, reaching the cancellous bone.
Sponsors
First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.End-stage knee osteoarthritis, classified as Kellgren-Lawrence grade III or IV, with knee varus or valgus deformity less than 15° and flexion contracture less than 15°; 2.Scheduled for primary unilateral total knee arthroplasty; 3.Aged between 20 and 80 years, regardless of gender; 4.Normal preoperative blood routine and coagulation profiles; 5.Voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with an allergy to tranexamic acid; 2.Severe cardiovascular, cerebrovascular, pulmonary, renal, or hematologic diseases; 3.Preoperative anemia and coagulation disorders; 4.Use of anticoagulant and other antiplatelet medications within 1 week before surgery; 5.History of thrombosis, myocardial infarction, stroke, malignancy, or hypercoagulable states; 6.Underwent major orthopedic surgery within 1 month prior to admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein;Erythrocyte sedimentation rate;Blood RT;Coagulation function;Thrombosis of both lower limbs;Hospital for Special Surgery knee score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factor panel;Bleeding event;VAS pain rating scale; | — |
Countries
China
Contacts
Public ContactLi Cao
First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed