cognitive dysfunction associated with sepsis
Conditions
Interventions
Control group:NA
Sponsors
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical center of Nanjing Medical University.
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Inclusion criteria for the sepsis group: The diagnostic criteria for sepsis set out in the Save Sepsis Campaign (SSC) guidelines published by the European Society of Critical Care Medicine and the American Society of Critical Care Medicine (ESICM/SCCM) in 2021 were met. 2) Inclusion criteria of control group: non-sepsis patients admitted during the same period.
Exclusion criteria
Exclusion criteria: 1. Have a history of neuropsychiatric diseases, such as cerebrovascular disease, central nervous system infection, dementia, epilepsy, Parkinson's disease, craniocerebral trauma surgery, etc., or the admission to the ICU with the above neuropsychiatric diseases; 2. Patients after cardiopulmonary resuscitation; 3. A history of coma or cognitive dysfunction before onset; 4. People with low intelligence and below primary school education; 5. Patients with history of hepatic encephalopathy, pulmonary encephalopathy, renal encephalopathy, hypothyroidism, etc.; 6. severe deafness, visual impairment, inability to communicate properly, etc., can not cooperate with the completion of the study related scale assessment; 7. A history of drug abuse, drug use, alcoholism and long-term use of psychotropic drugs; 8. Pregnant and/or lactating women; 9. Age =18 years or =80 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function scale;Head MRI image; | — |
Secondary
| Measure | Time frame |
|---|---|
| NLRP3;Gut microbiota; | — |
Countries
China
Contacts
Public ContactHui Jiaojie
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical center of Nanjing Medical University.
Outcome results
None listed