Acute Respiratory Distress Syndrome
Conditions
Interventions
The Oxalidine group:Oxalidine continuous infusion
Sufentanil group:Sufentanil continuous infusion
Sponsors
the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: The patients were admitted to the Department of Critical Care Medicine of the First Affiliated Hospital of Wannan Medical College and diagnosed with ARDS (diagnostic criteria: meet the new global definition of ARDS diagnostic criteria), aged > 18 years and 48 hours. The patients or their families had signed the informed consent
Exclusion criteria
Exclusion criteria: Pregnant or lactating women, the group in the first half of severe cardiac insufficiency, unstable angina and acute myocardial infarction, liver and kidney dysfunction (ALT and AST > 2 times more than normal, Cr > 2 times more than normal), respiratory depression or respiratory depression risk; Patients with gastrointestinal bleeding or perforation within six months, paralytic intestinal obstruction, acute pancreatitis, biliary tract disease, abdominal surgery within one month, history of gastrointestinal surgery, inflammatory bowel disease, gastrointestinal ulcer and other primary gastrointestinal function injury; Craniocerebral injury intracranial pressure; Long-term use of analgesics and/or gastrointestinal motility drugs and allergy to study drugs or opioids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For the first time defecation time;Total length of hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal barrier and intestinal motility;Hemodynamic indicators;Mechanical ventilation time;ICU hospitalization time;28 day mortality rate; | — |
Countries
CHINA
Contacts
Public ContactQun Chen
the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital)
Outcome results
None listed