MM and lymphoma
Conditions
Interventions
EAP group (Hematopoietic stem cell mobilization is performed using the EAP ):NA
CG group (Hematopoietic stem cell mobilization is performed using the CG ):NA
Sponsors
The Affiliated People's Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
25 Years to 72 Years
Inclusion criteria
Inclusion criteria: 1) Patients diagnosed with MM/lymphoma according to the 4th edition of the "Diagnostic and Efficacy Criteria for Blood Diseases"; 2) MM/lymphoma patients who meet the conditions for predicted/confirmed poor mobilization: "poor confirmed mobilization" is defined as (meeting any of the following:(1) 20 peripheral blood CD34+ cells on day 6 after mobilization with G-CSF alone <= or =5 µg/kg after chemotherapy) and after G-CSF alone on day 6 after mobilization or after chemotherapy combined with G-CSF (generally day 20); (2) CD34+ cells < 2×106/kg after = 3 apheresis. "Poor expected mobilization" is defined as (any of the following) :(1) previous collection attempts have failed; (2) Previous radiotherapy or adequate therapy that affects stem cell mobilization; (3) Advanced disease, refractory disease (= 2nd line chemotherapy), extensive bone marrow invasion during mobilization, hematopoietic tissue < 30%, or age = 65 years.; 3) There are indications for auto-HSCT.
Exclusion criteria
Exclusion criteria: Case data of patients with severe cardiac, pulmonary, hepatic and renal dysfunction were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of =2 × 106 CD34+ cell/kg;The rate of =5 × 106 CD34+ cell/kg; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of collections;Number of red blood cell transfusions;Number of platelet transfusions;Number of days of neutrophil recovery;Number of days of platelet recovery; | — |
Countries
China
Contacts
Public ContactPeipei Ye
The Affiliated People's Hospital of Ningbo University
Outcome results
None listed