Determination the ED90s of different concentrations of initial ropivacaine dose for labor analgesia with dural puncture epidural (DPE): A randomized sequential allocation study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400086367

Enrollment

Unknown

Registered

2024-06-29

Start date

2024-07-01

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

0.075% Group:10 mL of 0.075% ropivacaine with 0.3 µg/mL of sufentanil

0.1% Group:10 mL of 0.1% ropivacaine with 0.3 µg/mL of sufentanil

0.125% Group:10 mL of 0.125% ropivacaine with 0.3 µg/mL of sufentanil

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women aged 18-40 with a single term pregnancy who request epidural labor analgesia should have a cervical dilation of 5, and an American Society of Anesthesiologists physical status I-II.

Exclusion criteria

Exclusion criteria: Intraspinal analgesia is contraindicated; Hypertension (including chronic hypertension, hypertension, and preeclampsia during pregnancy), gestational diabetes mellitus, giant fetus, BMI >=40kg/m^2, fetal distress, or patients who use other methods of analgesia are all contraindications for this procedure. Additionally, the use of ropivacaine or sufentanil is also contraindicated.

Design outcomes

Primary

Measure	Time frame
The ED90 of initial ropivacaine dose with dural puncture epidural (DPE);	—

Secondary

Measure	Time frame
visual analogue scale (VAS) score;Bromage score;Apgar score;adverse event;	—

Countries

China

Contacts

Public ContactXiangsheng Xiong

Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an)

158193942@qq.com+86 177 9898 2001

Outcome results