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Explore biological mechanism of i-HECT in adolescent patients with depression on CNS-EV combined with proteomics

Explore biological mechanism of i-HECT in adolescent patients with depression on CNS-EV combined with proteomics

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400086324
Enrollment
Unknown
Registered
2024-06-28
Start date
2024-07-01
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Healthy control group:none
Experimental group (i-HECT group):i-HECT

Sponsors

Second People’s Hospital of Huizhou
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 25 Years

Inclusion criteria

Inclusion criteria: 1. Aged 15-25 years; 2. Hospitalized patients diagnosed as unipolar or bipolar depression according to DSM-5, with or without psychotic symptoms; 3. Baseline Montgomery Depression Scale (MADRS)> 22 points or associated with suicide risk; 4. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Be pregnant; 2. Those who have participated in other related research within 30 days before enrollment; 3. Received ECT or rTMS treatment within 6 months before enrollment; 4. The previous poor effect on ECT; 5. In the history of psychoactive substance abuse; 6. There are contraindications related to ECT; 7. There is anesthesia risk such as cardiovascular disease; 8. There is a history of epilepsy.

Design outcomes

Primary

MeasureTime frame
Response rate;

Secondary

MeasureTime frame
Cognitive function;

Countries

China

Contacts

Public ContactJia Li

Second People’s Hospital of Huizhou

icechristina@sina.com+86 752 218 2981

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026