Lung cancer
Conditions
Interventions
Conventional dose opioid group:Sufentanil was injected intravenously at 0.3 µg/kg during induction. Sufentanil was injected intravenously at 0.15 µg/kg before incision. Sufentanil 0.15 µg/kg was added
Low dose opioid group:During induction, sufentanil 0.15 µg/kg + esketamine 0.15 mg/kg were injected intravenously. Intravenous injection of sufentanil 0.075 µg/kg + esketamine 0.075 mg/kg before incis
PCIA formulation (sufentanil 0.015 µg/kg/h + esketamine 0.015 mg/kg/h + dexamethasone 15 mg + Ondansetron 12 mg) 72 hours after surgery.
Sponsors
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: The patients were selected to undergo a single or double-orifice unilateral thoracoscopic segmental resection or lobectomy, regardless of gender, aged 65-80 years, BMI 18-30 kg/m2, and ASA grade I-III
Exclusion criteria
Exclusion criteria: 1) contraindicated thoracic paravertebral block; 2) Serious heart, lung, liver and kidney diseases; 3) Patients with severe hypertension, glaucoma or elevated intracranial pressure, untreated or undertreated hyperthyroidism; 4) Chronic pain, alcoholism, psychosis and opioid dependence; 5) Mental illness or communication disorder; 6) Severe sleep and cognitive disorders, Athens Insomnia Scale (AIS) score =6, Mini-Mental Status Examination (MMSE) score =27 after admission; 7) People who are allergic to or addicted to esketamine active ingredients and excipients; 8) Patients who refused to participate in this study; 9) Transfer to open surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality scores were recovered 24 h, 48 h, 72 h after surgery;Incidence of chronic pain and pain intensity 3 months after surgery;Nightmares; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting and dynamic pain VAS scores 24 h, 48 h, 72 h after surgery;Ramsay sedation scores 24 h, 48 h, 72 h after surgery;The incidence and intensity of chronic pain and neuropathic pain 6 months after surgery;Assens Insomnia Scale (AIS) score 24 h, 48 h, 72 h after surgery; | — |
Countries
China
Contacts
Public ContactQun Fu
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Outcome results
None listed