Perimenopausal depression
Conditions
Interventions
Perimenopausal depression group:None
Non-perimenopausal depression group:None
Normal control group:None
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Perimenopausal depression group: 1. Female, aged between 18 and 65 years old; 2. Meets DSM-5 diagnostic criteria for major depressive disorder and the subject is in perimenopause with a Hamilton Depression Scale (HAMD-17) score >17; 3. No use of anti-anxiety drugs, antidepressants, antipsychotics or anticonvulsants in the last 1 month; 4. No use of prebiotics, probiotics and probiotic fermented foods within 1 month; 5. Not using any antibiotics in 1 month. Non-perimenopausal depression group: 1. Female, aged between 18 and 65 years old; 2. Meet the DSM-5 diagnostic criteria for major depressive disorder, and the subjects are in the non-perimenopausal period, with a Hamilton Depression Scale (HAMD-17) score > 17; 3. No use of anti-anxiety drugs, antidepressants, antipsychotics or anticonvulsants in the last 1 month; 4. No use of prebiotics, probiotics and probiotic fermented foods within 1 month; 5. Not using any antibiotics in 1 month. Normal control group: 1. Female, aged between 18 and 65 years old; 2. Do not meet the diagnostic criteria of DSM-5 major depressive disorder, Hamilton Depression Scale (HAMD-17) score = 7, and the subjects are in perimenopause; 3. No use of anti-anxiety drugs, antidepressants, antipsychotics or anticonvulsants in the last 1 month; 4. No use of prebiotics, probiotics and probiotic fermented foods within 1 month; 5. Not using any antibiotics in 1 month.
Exclusion criteria
Exclusion criteria: 1. People with organic brain lesions (such as cerebral haemorrhage, massive cerebral infarction, encephalitis, epilepsy); people with chronic systemic diseases that can affect the central nervous system and the digestive system; people with systemic systemic diseases (such as autoimmune diseases) that are not well controlled. 2. Those who suffer from inflammatory bowel disease, pancreatitis, gastrointestinal tumour and other digestive system diseases; 3. Obesity: BMI = 28.0; Hyperglycemia: FPG = 6.1mmol/L and/or 2hTC = 7.8mmol/L and/or those who have been diagnosed with diabetes mellitus and have been treated; TG = 2.3mmol/L; Hypertension: systolic blood pressure = 140mmHg or diastolic blood pressure = 90mmHg; 4, Those with severe dietary imbalance, such as high-fat diet preference or long-term vegetarians; 5. Suffering from other mental disorders that meet the DSM-5 diagnostic criteria (except anxiety disorders and insomnia disorders); 6. Pregnant and lactating women; 7. Refusing to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal sample test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Near Infrared Brain Function Test;Hamilton depression scale;Hamilton Anxiety Scale;Self-rating depression scale;Self-Rating Anxiety Scale;Pittsburgh sleep quality index;Global Assessment Function; | — |
Countries
China
Contacts
Public ContactYihuan Chen
Department of psychiatry, Xijing Hospital
Outcome results
None listed