Obese patients who require painless gastroscopy
Conditions
Interventions
Normal group:Sufentanil (0.1ug/kg) + ciprofol dose determined by modifed Dixon’s up and down method. In the first patient, ciprofol dose was 0.4mg/kg and the dose gradient was 0.01mg/kg. The ‘movement
Obesity group:Sufentanil (0.1ug/kg) + ciprofol dose determined by modifed Dixon’s up and down method. In the first patient, ciprofol dose was 0.4mg/kg and the dose gradient was 0.01mg/kg. The ‘movemen
Sponsors
The First People’s Hospital of Yancheng
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1) Age: 18-64; 2) 18.5=BMI<24.0 kg/m2 or BMI=28 kg/m2 3) ASA grade I-III patients undergoing painless gastroscopy.
Exclusion criteria
Exclusion criteria: 1)Patients who were allergic to sedative/anesthetic drugs such as sufentanil and cyclopofol or had a history of severe allergy; 2) Patients who had contraindications to endoscopy or were refused to anesthesia; 3) Patients without accompanying family members; 4) Uncontrolled severe hypertension (SBP=180mmHg, DBP=110mmHg); 5) Patients with recent acute respiratory infection, acute attack of asthma, acute attack of COPD or preoperative combination of hypoxemia; 6) Acute coronary syndrome, severe arrhythmia, heart rate failure; 7) Massive hemoptysis in active period; 8) Severe anemia (Hb < 6g/dL) 9) Patients with mental system diseases and cognitive dysfunction who cannot communicate normally; 10) Have a history of psychotropic and narcotic drug abuse; 11) Liver dysfunction (Child-Pugh grade C or above); Renal dysfunction (CKD3 stage or above); 12) Pregnant or lactating women; 13) Acute upper gastrointestinal bleeding with shock, pyloric obstruction, achalasia of cardia, gastric emptying disorder, and a history of upper gastrointestinal surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The median effective dose of ciprofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of perioperative hypotension;Incidence of perioperative bradycardia;Incidence of perioperative hypoxemia;Incidence of postoperative nausea and vomiting;Patient satisfaction;Endoscopist satisfaction;The recovery time of patient;The length of stay in the PACU; | — |
Countries
China
Contacts
Public ContactZhouya Xue
The First People’s Hospital of Yancheng
Outcome results
None listed