skin degloved injury
Conditions
Interventions
Control group:1) Debridement is performed on the subjects to remove the clearly necrotic tissue and leave the skin tissue that could survive in situ for replantation.
2) Dress the wound with sterile g
Sponsors
department of Orthopedic surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Extremity skin avulsion injuries or stealth detachment injuries caused by various causes 2) The time from injury to initial debridement is less than or equal to 72 hours 3) With or without bone fracture 4) The surface area of the skin avulsion wound is greater than 5*5cm 5) 18-65 years old
Exclusion criteria
Exclusion criteria: 1) Active cellulitis 2) Osteomyelitis 3) History of open injury or scarring of the previous injured area 4) Combined thoracoabdominal and cerebral injuries, unstable vital signs, unable to tolerate multiple limb-salvage surgeries 5) Revascularization was performed in the last 6 weeks(Ipsilateral lower extremity) 6) Taken any experimental drug or applied topically to the wound 4 weeks prior to the study 7) Presence of significant medical conditions that would impair wound healing, such as aplastic anemia, liver disease, scleroderma, malignancy, or immunosuppressive therapy 8) Patients who are participating in other clinical trials 9) Specimen collection was not satisfactory 10) Vulnerable groups, including people with mental illness, cognitive impairment, critically ill patients, minors, pregnant women, etc. 11) Other reasons that are considered unsuitable by the investigators to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound area;Immunofluorescence; | — |
Secondary
| Measure | Time frame |
|---|---|
| RNA sequence; | — |
Countries
China
Contacts
Public ContactXianfeng Lin
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed