postoperative sleep disturbance
Conditions
Interventions
C group:General anesthesia + intraoperative infusion of physiological saline + postoperative pain relief with sufentanil
S group:General anesthesia +intraoperative infusion of esketamine + postoperative analgesia with a combination of sufentanil and esketamine.
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective thoracoscopic lobectomy; 2.Male or female, aged 18-75 years, ASA classification I-III, BMI 18-30 kg/m²; 3. Subjects voluntarily participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to or contraindicated for the study drug; 2. Contraindications to regional or general anesthesia; 3. Poorly controlled or untreated hypertension; 4. Poorly controlled blood glucose (random blood glucose =11.1 mmol/L); 5. Significant abnormalities in preoperative liver function (AST or ALT =1.5×ULN; TBIL =1.5×ULN) and/or kidney function (Cr =1.5×ULN); 6. Pregnant or lactating women; 7. Conversion to open thoracotomy or occurrence of severe adverse events during surgery; 8. Combined psychiatric or neurological disorders; 9. Surgery ending later than 19:00 on the same day; 10. History of previous chest surgery or chest trauma; 11. Inability or refusal to cooperate; 12. Other conditions deemed unsuitable for participation in this clinical trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of Postoperative sleep disturbance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative VAS scores;Postoperative anxiety and depression scores;The incidence of postoperative delirium;Postoperative morphine consumption.;Consumption of opioid analgesics during surgery;Postoperative serum inflammatory factors;Consumption of vasopressor drugs during surgery.; | — |
Countries
China
Contacts
Public ContactShan Guoliang;Jin Yanwu
The Second Hospital of Shandong University
Outcome results
None listed