Degenerative lesions of the lumbar spine
Conditions
Interventions
Esketamine Group (S Group):? After the surgical position was placed, the loading dose of dexmedetomidine was injected immediately (0.5µg/kg, 10 minutes)
Esketamine was also pumped at 0.02mg/kg/h
? After disinfection, sufentanil was given 0.05µg/kg
Control group (Group D):? After the surgical position was placed, the loading dose of dexmedetomidine was injected immediately (0.5µg/kg, 10 minutes)
At the same time, 0.02ml/kg/h pump was injected with equal volume of normal saline
? After disinfection, sufentanil was given 0.05µg/kg.
Sponsors
he Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old, male or female, ASA grade I-III; 2. Patients with single level lumbar disc herniation, lumbar disc disease and other patients requiring PELD surgery; 3. Intravenous anesthesia is planned; 4. Voluntarily participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients refused to participate in the study 2. Bmi higher than 30, 3. Obstructive sleep apnea syndrome or STOP-Bang score was 3 4. Preoperative Pittsburgh Sleep Quality Index (PSQI) was higher than 7 5. Drug allergies 6. Stroke and multiple trauma within 6 months before surgery 7. Use of psychotropic substances, night shift, reluctance to participate in research, or unexpected discharge 8. Preoperative delirium, Parkinson's disease, dementia, communication difficulties, severe hearing or vision impairment 9. Congenital heart disease or other serious cardiovascular disease above NYHA level III
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative moderate to severe pain rate;Macnab score of lumbar function;Drug-related adverse events;Use of vasoactive drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital signs;hospital stays;Health status SF-36 score;Incidence of PSD ;vas score;Postoperative anxiety and depression scores;ODI score for low back pain;24 h after surgery patients and surgeons satisfaction of anesthesia; | — |
Countries
China
Contacts
Public ContactJin Yanwu
The Second Hospital of Shandong University
Outcome results
None listed