Type 2 diabetes
Conditions
Interventions
NO-OCH group:Patients were given 400 ml of flavored water at 2 hours before the initiation of anesthesia
OCH group:Patients were given 400 ml of oral carbohydrate solution at 2 hours before the initiation of anesthesia
Sponsors
the Second Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria will be: (1) Male or female subject previously diagnosed as T2DM in accordance with the criteria set forth by World Health Organization (WHO) ; (2) Age between 18 to 65 years; (3) American Society of Anesthesiologists (ASA) grade II - III, surgery for upper extremity fractures (humerus, ulna and radius fractures) and lower extremity fractures (femoral shaft, patella, tibia, fibula, knee and ankle fractures); (4) Hemoglobin A1c (HbA1c) = 70 mmol/mol; (5) Body mass index (BMI) 18 to 30 kg/m2; (6) agree to participate in the study and provides written informed consent.
Exclusion criteria
Exclusion criteria: (1) Weight loss greater than 10 per cent during the previous 6 months; (2) Renal insufficiency (creatinine, > 3 mg/dl; hemodialysis); (3) Hepatic insufficiency (Child-Pugh class = B); (4) Gastro-oesophageal reflux disease; (5) Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate; (6) Alnutrition or severe anemia disease: ALB < 35g/L, Hb < 90g/L; (7) Electrolyte Imbalance, abnormal blood coagulation, pregnancy, sleep disorders; (8) history of drug allergy; (9) Participation in another trial with an investigational drug within 30 days before informed consent; (10) Treatment with systemic steroids, antipsychotic drugs or cancer therapeutics such as glucocorticoids, chemotherapy, hormonal therapies and targeted drugs which may induce insulin resistance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HOMA-IR; | — |
Secondary
| Measure | Time frame |
|---|---|
| thirst, hunger, and nausea;Anxiety ;HOMA-IR at other time point;Postoperative comfort outcomes;Quality of sleep;nausea and vomiting after surgery;postoperative fever;the indwelling time of the drainage tube;the first oral feeding time;the first bowel sounds time; total duration of postoperative hospitalization; | — |
Countries
China
Contacts
Public Contactzhaoyang xiao
The Second Affiliated Hospital of Dalian Medical University
Outcome results
None listed